A statement on Wigan's official website read: "Wigan Athletic can confirm that Mauro Boselli has joined Italian Serie A side Palermo on loan until the end of the season with an option to buy at the end of the term."
Boselli has made 12 appearances for Latics so far this season and scored four goals in all competitions.
It will be his second spell in Italy after a loan stint at Genoa last season which returned just one league goal from six appearances.
Boselli joined Wigan in 2010 from Estudiantes, to whom he returned for a loan spell at the beginning of the 2011-12 campaign.
In all competitions he has made 24 appearances and scored five goals for Roberto Martinez's men.
Palermo confirmed Boselli's arrival at the Stadio Renzo Barbera with a brief statement on their official website, with the striker set to be unveiled at a press conference scheduled for 1pm BST on Tuesday.

City have not been actively trying to sell Balotelli, who has never been far from the headlines with a series of on- and off-field antics, but if he were to leave the club in this month's transfer window it would not be on a loan deal.
Balotelli joined City from Inter Milan in 2010 for around £24m and has had a sometimes troubled time at the club, including clashes with manager and compatriot Roberto Mancini and disciplinary issues.

Fulham have won just two of their previous 17 Premier League matches against West Ham (W2 D5 L10), with one of those victories being in their first ever PL meeting.
Only Arsenal (7) have won more often away at Fulham in the Premier League than West Ham United (6).
The Whites have failed to find the net in four of their previous eight Premier League home games against West Ham, netting only six goals in total.
Fulham have a lower win percentage than any other club in Premier League London derbies (19.4%) and have won just two points from a possible 15 in PL London derbies this season.
Only Arsenal (50.8%) and Chelsea (49.2%) have a better win percentage in Premier League London derbies than West Ham United (31.6%).
Carlton Cole has scored in each of his last five Premier League starts against Fulham, netting six goals in total, however, he also scored an own goal in this run. These six goals mean that he’s scored more often against Fulham than any other side in the Premier League.
West Ham have conceded fewer headed goals than any other Premier League side this season (1).
The Hammers have played a higher proportion of their passes in the attacking third of the pitch than any other side in the Premier League this season (39.2%).
No goalkeeper has been forced into making more saves than Jussi Jääskeläinen (91).
Dimitar Berbatov netted five goals in his first seven Premier League appearances for Fulham (goal every 117 mins), but has scored only two in his subsequent 12 PL games (goal every 540 mins).
Mark Noble has created more goalscoring chances without having assisted a goal (32) than any other player in the Premier League this season.
BETTING ODDS
Fulham 6/5, Draw 5/2, West Ham 5/2

The Red Devils have dropped just two points in 13 Premier League home games against Southampton (W12 D1).
Manchester United have scored in 25 of their 27 previous Premier League games against Southampton and have scored at least twice in eight of their last nine PL games versus them.
Robin van Persie has scored four goals in three Premier League appearances against Southampton, including a hat-trick in Manchester United’s 3-2 win at St Marys earlier this season.
Morgan Schneiderlin has made more tackles than any other player in the Premier League this season (90) and only Sandro (80) has made more interceptions than the Frenchman (72).
Paul Scholes has been given six cautions in the Premier League this season, despite playing only 682 minutes; meaning he has been given a yellow card every 114 mins on average.
Wayne Rooney has scored five goals in his last five Premier League appearances and has three goals in his last three PL games against Southampton.
Manchester United have currently won 299 home games in the Premier League; more than any other side.
Manchester United have seen 16 different players score a Premier League goal for them this season; more than any other side.
The Red Devils have won 29 of a possible 33 points from their last 11 Premier League games (W9 D2).
Southampton have lost none of their last six Premier League matches, but five of these have ended in a draw (W1 D5).
BETTING ODDS
Manchester United 1/4, Draw 11/2, Southampton 13/1

Premier League - Match facts: Reading v Chelsea

Match facts and odds ahead of the Premier League game between Reading and Chelsea at the Madejski Stadium on Wednesday.

Reading have won just one point in their previous five Premier League meetings with Chelsea (D1 L4).
Reading have lost a league-high 20 points from leading positions this season, with three of these points coming in the reverse fixture, as Reading led 2-1 until the 69th minute and eventually lost 4-2 at Stamford Bridge.
Chelsea have scored the first goal of the game on more occasions than any other Premier League side this season (15).
Reading have won only one of their eight Premier League games (13%) that they have scored the first goal of the game in this season.
Despite refereeing only 11 matches in the Premier League this season, Mark Halsey has awarded six penalties. Only Phil Dowd (8) has given more.
Chelsea have won a league-high eight penalty kicks this season in the Premier League.
Five different players have taken these eight penalties for Chelsea, Frank Lampard (4), Eden Hazard, Oscar and Fernando Torres score theirs, while Lucas Piazon was the only one to miss.
Adam Le Fondre has scored with four of his last five shots (excl. blocked) in the Premier League.
This will be Rafael Benitez’s 12th Premier League game in charge of Chelsea and he’s won 21 points so far. Roberto Di Matteo won 24 points in his 12 PL games in charge of the Blues this term.
Reading have won nine points from their last four Premier League games (W3 L1). They had collected just 10 in their previous 19 PL matches this term.
BETTING ODDS
Reading 13/2, Draw 7/2, Chelsea 1/2